Screen Gems, de studio achter de Resident Evil-films, heeft de rechten op The Last of Us in handen gekregen. De PlayStation 3-titel zal naar het grote scherm gebracht worden. Eén van de producenten is Sam Raimi, bekend van The Evil Dead en Spider-Man. De screenplay zal geschreven worden door Neil Druckmann, de Creative Director van het spel. Hij zal met Raimi de film produceren, alsook met Naughty Dog presidenten Evan Wells, Christophe Balestra en Game Director Bruce Straley. Wells zei het volgende:
Our partnership with Sam Raimi, Ghost House Pictures, and Screen Gems to develop a film based on The Last of Us universe is a perfect fit. Since our game released last June, we’ve talked with many companies about making a film, but we couldn’t have found better partners who share our creative vision and high standards. We look forward to collaborating with Sam, his team, and Screen Gems, to make a movie that will thrill fans of The Last of Us and general audiences worldwide.